Sentence examples for bioavailability of this agent from inspiring English sources

Assuming that the pharmacokinetics of NU7026 are linear, the i.p. and p.o. bioavailability of this agent are 20 and 15%, respectively.

In this study, we set out to determine whether 667 COUMATE is sequestered into RBCs, as this may explain the high bioavailability of this agent despite its relatively high clearance rate.

Biological barriers are the first defense system, limiting the bioavailability of the agents, and exist in the skin, mucosa, and the perineural structures.

The different results obtained with the neutralizing VEGF antibodies and the VEGFR kinase inhibitor may result from the use of different species (rats vs. mice), from different bioavailability of the agents or from differences in their efficiencies in blocking VEGF action.

PD0325901 is a potent MEK inhibitor with chemical characteristics similar to that of CI-1040; however, a better oral bioavailability makes this agent more suitable for in vivo studies [ 19, 24].

It was shown that neither ADP induced platelet aggregation nor the bioavailability of either agent was significantly altered by the combined therapy which is in line with our findings.

The pharmacodynamics studies on serially collected PBMC and tumor biopsies revealed limited bioavailability of UCN-01 to tissue, likely as a result of the high affinity binding of this agent to the α1-acid glycoprotein (AAG) [ 28, 39– 41].

Transdermal and topical delivery systems ensure additional advantages over other delivery routes, viz.: provide enhanced biocompatibility by evading the hepatic first-pass metabolism, support patient compliance by decreasing the drug dosage and at the same time maintaining the therapeutic effect of the drug, and enhance the bioavailability of the therapeutic agent at the targeted tissue or cells.

When 2 years ago Hackett discovered a new way of using a lipid to link drugs to the soluble protein albumin, and that the combination showed promise in improving the bioavailability of the chemotherapy agent paclitaxel, he and his adviser thought they had an invention that laid the foundation for a company.

Indeed, a diverse array of therapeutic agents can be incorporated into nanoparticles and administered at the site of action, thereby increasing the bioavailability of the therapeutic agent.

The stability and bioavailability of anticancer agents, such as gemcitabine, can be increased by forming prodrugs.