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The absolute bioavailability of the tablets ranges between 30 and 42 % largely due to presystemic hepatic metabolism [3, 4].
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The parametric 90% confidence intervals for the different parameters were higher than the commonly expected intervals for bioequivalency, indicating greater bioavailability of the liquisolid tablets.
32 The bioavailability of both the SubQ and IV routes of administration is 100%, and the bioavailability of the oral tablet is about 18%.
4– 10 Darunavir is available as an oral suspension (100 mg/ml), with comparable bioavailability to the tablet formulations.
Bioavailability assessments performed with the 25 and 150 mg tablets indicated that the relative bioavailability of the 150 mg tablet formulation is less when compared with the 25 mg tablet formulation.
In fasting conditions, the time to peak drug concentration is approximately 1 h, with an absolute bioavailability of the film-coated tablets of around 40%% following gastrointestinal and hepatic first-pass metabolism [ 44].
The relative bioavailability of the Ca PAS tablet was 87.4%.
A significantly decreased Cmax, prolonged Tmax and satisfactory bioavailability of the osmotic pump tablet were obtained, and a good in vivo in vitro correlation of the two drugs was also established.
However, the variable bioavailability of itraconazole tablets and poor tolerability of itraconazole suspension may limit its use as a prophylactic agent (Vardakas et al, 2005; Cornely et al, 2007; Simon et al, 2007).
The absolute bioavailability of the drug from the liquisolid tablets was 15% higher than that from the commercial one.
The relative bioavailability of the floating pellets compared with reference tablets was 113.06 ± 23.83%.
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