Sentence examples for bioavailability of the agents from inspiring English sources

Biological barriers are the first defense system, limiting the bioavailability of the agents, and exist in the skin, mucosa, and the perineural structures.

The different results obtained with the neutralizing VEGF antibodies and the VEGFR kinase inhibitor may result from the use of different species (rats vs. mice), from different bioavailability of the agents or from differences in their efficiencies in blocking VEGF action.

Flurbiprofen did not seem to alter the bioavailability of the chemotherapeutic agents.

Indeed, a diverse array of therapeutic agents can be incorporated into nanoparticles and administered at the site of action, thereby increasing the bioavailability of the therapeutic agent.

Transdermal and topical delivery systems ensure additional advantages over other delivery routes, viz.: provide enhanced biocompatibility by evading the hepatic first-pass metabolism, support patient compliance by decreasing the drug dosage and at the same time maintaining the therapeutic effect of the drug, and enhance the bioavailability of the therapeutic agent at the targeted tissue or cells.

When 2 years ago Hackett discovered a new way of using a lipid to link drugs to the soluble protein albumin, and that the combination showed promise in improving the bioavailability of the chemotherapy agent paclitaxel, he and his adviser thought they had an invention that laid the foundation for a company.

In this study, we set out to determine whether 667 COUMATE is sequestered into RBCs, as this may explain the high bioavailability of this agent despite its relatively high clearance rate.

Assuming that the pharmacokinetics of NU7026 are linear, the i.p. and p.o. bioavailability of this agent are 20 and 15%, respectively.

Selection for ARB will depend on the type and in situ bioavailability of selecting/coselecting agents, the abundance of bacterial host, and the abundance of AR determinants.

A promising method to improve the bioavailability of pharmaceutical agents is the rapid expansion of supercritical solutions.

Although encouraging advances have been achieved in the last few years, the specificity and oral bioavailability of the new chemotherapeutic agents seem to pose a challenge to medicinal chemists.