Sentence examples for bioavailability of peptides from inspiring English sources
However, there are several reasons that cause reduced oral bioavailability of peptides and proteins.
Such interactions can reduce the bioaccessibility and bioavailability of peptides, and can also alter their biological activities when measured using in vitro assays.
Low bioavailability of peptides is a major factor that limits their application and often attributed to their selective intestinal uptake and physiological instability when consumed orally.
To increase the low bioavailability of peptides and proteins such as EGF in conventional topical solutions, viscous drug delivery systems such as sponge have been explored [ 7].
Most studies of bioavailability of peptides released during protein hydrolysis process relate to changes caused by a single proteolytic enzyme or subsequent hydrolysis resulted in proteases of the digestive system, bypassing the step α-amylase hydrolysis.
N-Methylation is a common strategy for improving oral bioavailability of peptide-based lead structures.
Our work presents an effective design strategy for optimizing natural antiviral peptides and opens a new avenue for enhancing the bioavailability of peptide drugs.
Accordingly, it has been under extensive investigation as a possible strategy to improve the oral bioavailability of peptide and protein drugs.
Moreover, azapeptides were shown to be more stable in biological medium compared to native peptides, and for this reason, they have been used to improve the stability and bioavailability of peptide drugs.
The goal of this review is to compare these two drug delivery approaches from a physico-chemical and a biopharmaceutical standpoint in an attempt to define how nanotechnology-based products can be differentiated from standard oral dosage forms for oral bioavailability of diabetes peptides.
In this study chitosan-dextran-PVP gel (CDP gel) prepared as a novel and suitable gel based drug delivery system intended to increase the bioavailability of therapeutic peptides and proteins such as EGF toward wound tissue.
