Sentence examples for bioassay models from inspiring English sources

Many previous studies have demonstrated the acute toxicological effects induced by MCYSTs in fish using carps as bioassay models.

Although additional efforts are needed to establish advantages and disadvantages with our bioassay, models featuring intratracheal instillation clearly can be useful for detection of acute or subacute lung toxicity due to inhaled fine particles by using histopathological scoring and markers like BrdU and iNOS for screening purposes in short-term studies.

We have therefore developed and applied an in-vitro screen to triage and prioritize candidate modifier genes for more detailed future studies which is faster, far more cost effective and ethical relative to mouse bioassay models.

In the present study, we used an estrogen-responsive human cancer cell line, MCF-7, and the OVX mouse as bioassay models to assess the estrogenicity of DE-71, a standard Penta-BDE mixture of PBDEs commonly used in consumer goods.

Núñez-Pons et al. [63] reported feeding bioassay model using two predator organisms; starfish Odontaster validus and an amphipod Cheirimedon femoratus and suggested amphipod model is suitable for estimation of unpalatable chemical defence against predators in Antarctic communities.

Immature or ovariectomized (OVX) adult rodents have served as the standard bioassay model for estrogenic activity.

Included in the model are data from two large rat bioassays, modeling of flux of formaldehyde into respiratory tissues in both rats and humans, data on proliferation rates of cells in the rat nasal epithelium, and data on formaldehyde- related levels of DNA protein cross-links in rat nasal tissue.

This once again leads back to the question of whether primary screening data should be solely used to build bioassay predictive models - better models may be built using the confirmed Active compounds only.

Intracranial inoculation, reportedly a more sensitive route of prion exposure [16], [20], is more easily performed in mouse bioassay, a model which also permits extended incubation periods and inclusion of a greater number of test animals.

Although brain homogenates from these animals are not infectious in bioassays, these models suggest that a disproportionate change in the physiological function of PrPC is as neurotoxic as the gain of toxic function by PrPSc.

For the strains used in the cross-phylogeny bioassay, the model was General Time Reversible (GTR) with among-site substitution rate variation (R[A-C] = 0.6331, R[A-G] = 1.3004, R[A-T] = 0.8053, R[C-G] = 1.6249, R[C-T] = 2.4121, and R[G-T] = 1.0000), the proportion of invariable sites (I) being 0.4427, and a gamma distribution shape parameter (G) of 0.6005.