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Patient demographics are shown in Table 2. IFNβ treated patients with serum titres of 20 neutralizing units/ml or greater for two consecutive measurements at a 3 month interval using the cytopathic effect (CPE) bioassay (measures the serum concentration required to neutralize the antiviral activity of the IFNβ) were considered NAB+ve [35].
In contrast, the Ames micro-suspension bioassay measures base substitution and frameshift mutagenesis.
The mouse bioassay measures active toxin and is sensitive.
The bioassay measures the growth inhibition of L1210 leukemic cells after 48 h incubation.
The ToxiLight BioAssay measures the conversion of adenosine diphosphate to adenosine triphosphate (ATP) in the presence of AK.
After fitting a Poisson regression (see the section Materials and Methods) to repeated plant bioassay measures among all populations, we found that the R for the population term in the model was 0.33.
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Recently, we developed a novel bioassay measuring the levels of BP released from discarded ONJ bone, using chelation with EDTA and EGTA as the mechanism for release [ 28].
In two thirds of the samples, the bioassay measured a strong inhibition of circulating TNF-α-related activity during the first infusion.
The apoptosis bioassay measured the rituximab-induced externalization of phosphatidylserine on Raji B cells using Annexin V-FITC, while dead cells with permeabilized cell membranes were stained with propidium iodide.
A new bioassay measuring HER2 receptor internalization by ILs and performed ex vivo on breast tumor cells or explants appears capable of identifying a subset of HER2 overexpressing breast tumors that may not respond to some HER2 receptor-targeted therapeutics.
The concentration of the pro-inflammatory cytokine TNF in CSF was determined with a bioassay, measuring the degree of cytotoxicity on WEHI cells in the presence of 1 μg/ml actinomycin D, and with use of mouse rTNF as a standard.
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