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Bioactive molecules can be incorporated into such grafts to facilitate cellular recruitment.
Owing to the facile fabrication technique that uses benign solvents, bioactive molecules can be encapsulated within these protein matrices.
Moreover, various solid fillers such as hydroxyapatite fibers, as well as bioactive molecules can be employed as additives.
These bioactive molecules can be attached in a defined spectrum, concentration and spatial distribution in order to control adhesion, growth, viability, differentiation, and function of the cells.
Tailoring polypyrrole (PPy), an electroactive polymer, with functional groups to which a variety of bioactive molecules can be tethered is highly attractive for building biological structures on conducting surfaces for a range of biomedical applications.
This chapter first discusses the possibility of using synthetic peptides instead of native proteins, then it presents the different means by which bioactive molecules can be delivered to tissue-implant interfaces and the criteria for bioactive surface design.
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Bioactive small molecules can be used to identify novel signalling nodes and unravel redundant networks.
Although R. caffra is a sparsely populated remnant tree species that is purely selfing, hence the threats of gene flow is limited, it should be domesticated under controlled conditions where the bioactive molecules can then be extracted and used for medicinal purpose.
(a) Bioactive molecules with an amine such as cRGD and NTA-amine can be linked through the NHS moiety and the molecule can be attached to any material with an azide functional group through CuAAC.
This demonstration of sortase-mediated ligation of bioactive molecules to hydrogels will likely contribute to the development of improved culture systems for in vitro models, by expanding the repertoire of bioactive molecules that can be covalently attached to PEG to include large peptides and proteins.
The bioactive molecules that can be released by these same stem cells are starting to be identified and are likely effectors/candidates for the therapeutic effect.
More suggestions(18)
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