There is a growing interest in designing nanoemulsions intended for oral ingestion that have beneficial health effects, such as increasing the bioavailability of bioactive agents, targeting delivery of bioactive agents to specific regions of the gastrointestinal tract (GIT), or eliciting specific hormonal responses (such as hunger, satiety, or satiation).
Scaffolds containing NPs loaded with bioactive agents can be used for their local delivery, enabling site-specific pharmacological effects such as the induction of cell proliferation and differentiation, and, consequently, neo-tissue formation.
This could indicate that telomere content in tumors is influenced by the effects of bioactive compounds, such as TNF- α, on the expression of telomere-associated proteins.
3 The beneficial effects of spices and their bioactive ingredients such as capsaicin have long been documented in experimental or small sized population studies.
The European guidance is also the first to take into account the possibility of environmental effects from extremely low concentrations of bioactive substances, such as endocrine disruptors.
Understanding the mechanisms by which bioactive substances such as curcumin exert their pharmacological effects is essential for maximizing the health benefits.
Such a "U-shape" dose-effect curve has been reported for many cytokines and bioactive molecules, such as interferon-α, PPARγ ligands and endostatin which all exhibit a biphasic effect on angiogenesis [58] [62].
Our current study provides a new strategy of utilization of natural existing bioactive peptides, such as ACBP-L used in this study, to potentiate chemotherapeutic effects and minimize toxic effects.
However, in some bioactive compounds such as chlorophylls and total carotenoids, the effect was appreciable only in the first days of storage.
In the last decades, lots of epidemiological studies were focused on bioactive phytochemicals such as phenolic compounds due to their beneficial effect on human health.
