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The purpose of this review is to discuss the evidence that various dietary bioactive compounds can modulate cellular senescence in vitro and to summarize findings and mechanisms that might be useful for the development of health-promoting nutraceuticals.
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Furthermore, ionic compounds can modulate enzyme activity.
Contaminants occur in complex mixtures whose composition varies spatially and temporally, and we now appreciate that transformation products of bioactive compounds can themselves retain bioactivity.
These observations suggest that these bioactive compounds can have strong antioxidant properties.
On the other hand, the discovery of new activities of physiological, bioactive compounds can provide the basis for novel investigations in pathophysiological fields.
When dealing with mixtures, identifying the individual bioactive compounds can be a cumbersome endeavor.
The sustained release of these bioactive compounds can naturally preserve consumer products thereby increasing shelf life.
New sources of bioactive compounds can be created in the form of genetically encoded small molecule libraries.
Bioactive compounds can be general irritants acting on the peripheral sensory system, or toxins of specific physiological action [ 26].
Since cell contact with the biomaterial surface significantly influences cell behavior and performance, trends in biomaterial designs lean towards bioactive materials that can modulate and control cell behavior.
Chemical compounds can also modulate SG formation by affecting translation, proteasome activity or endogenous stressors (Mahboubi and Stochaj, 2017).
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