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Poly(ε-caprolactone) is commonly used in bone tissue engineering; the bioactivity of this polymer can be further improved through the incorporation of bioactive agents such as hydroxyapatite.
Scaffolds that release bioactive agents such as drugs offer additional benefits in this regard in comparison to those whose main requirements are space filling and load bearing.
Finally, recent examples of the utilization of biopolymer microgels to encapsulate, protect, or release bioactive agents, such as pharmaceuticals, nutraceuticals, enzymes, flavors, and probiotics is given.
PHA matrices are also being examined for encapsulation of bioactive agents, such as tumor drugs and antibiotics, to be inserted and delivered at the site of tissue distress ([Chee et al. 2008]).
On the other hand, some bioactive agents such as proteins, nucleic acids, or enzymes administered though oral or intravenous routes can be easily degraded by metabolism or by enzymatic conditions and are unable to reach the desired sites [1 3].
Hydrogels are used for targeted, controlled, and sustained drug delivery of bioactive agents such as anticancer, antimalaria, antibacterial drugs, etc., resulting in enhanced therapeutic effects when compared to the conventional administration of these drugs [3, 4].
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Given that aberrant activities of polyisoprenylated proteins play an important role in a majority of colon cancer progression cases [ 32] and PMPMEase inhibition has such a profound negative effect on cancer cell viability [ 33– 35], the current study was aimed at determining if PMPMEase may constitute a pharmacological target for bioactive anticancer agents such as curcumin.
Bioconjugate chemistry can be used to link specific binding motifs and bioactive molecules to imaging agents, such as superparamagnetic particles for MRI or radionuclides for PET and SPECT imaging [ 5, 12].
For example, marine actinobacteria have now been recognized as an abundant source of novel bioactive compounds yielding promising anticancer agents such as salinosporamide A (from the genus Salinispora), antibiotics such as taromycin (from the genus Saccharomonospora), and other drug leads.
Recently, bioactive glass nanoparticles doped with antimicrobial agents such as silver, zinc, and magnesium ions have been widely used for clinical applications [ 5– 8].
To extend this aspect to the temporary therapeutic applications in sustained delivery, the aqueous solution may be an aqueous medium alone, such as PBS, or an aqueous medium containing an antigen or a bioactive substance such as peptides, anticancer agents, hormones, or other active agents such as antibiotics or antiparasitics.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com