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A novel bio-pathway has been explored to convert CO2 into formic acid by the aid of formate dehydrogenase (FateDH) as the biocatalyst and reduced nicotinamide adenine dinuncleotide (NADH) as the terminal electron donor.
Genes in bold are contained in the bio-pathways.
Enrichment analysis of bio-pathways were performed using DAVID 6.7 bioinformatic resources [ 61].
Synthetic biology approaches need pools of "genetic elements" to mix and match to build and optimize synthetic bio-pathways.
Despite of a growing need for simulation-aided studies on bio-pathways, some fundamental issues prevent us from drawing their full potentials.
The five patterns, each from a dataset, are shown in Table 4. : in this column, X/Y denotes that the subsequential pattern contains Y genes and × genes are in the corresponding bio-pathways.
The discovery of new fluorinases and biosynthetic pathways increases the genetic resource of bio-fluorination and will benefit the future development of synthetic bio-pathways to produce fluorinated natural products.
This tool identifies annotation categories including GO terms, protein-protein interactions, protein functional domains, disease associations, bio-pathways, sequence general features, homologies, gene functional summaries, gene tissue expressions and literatures that are significantly enriched within the gene list [n.b. following multiple sample correction according to 20].
Each of the four patterns has significant overlapping genes with the bio-pathway, and they totally have 17 genes in the bio-pathway.
How these genes are involved in the bio-pathway is shown in Figure 6(a).
Figure 6 clearly illustrates that filtered patterns are useful to uncover those genes in a same bio-pathway.
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