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We carried out a binomial test to identify overrepresentation of GO classes for genes with HCP versus LCP.
We employed a binomial test to identify pathways consistently overrepresented among gene families with positive selection on insertions/deletions of different length in varying secondary structural elements.
Given these discrepancies, to provide additional validation for the use of a multiple span binomial test to identify regional expression biases, REBs were also identified from a set of gene expression data derived from clear cell renal cell carcinomas (ccRCC).
Most of these studies applied the one-tailed binomial test to identify significantly mutated genes, followed by a false discovery rate procedure to control for multiple testing (Benjamini and Hochberg 1995).
For simplicity, we term this approach IR-CGMA, for Improved Resolution-Comparative Genomic Microarray Analysis keeping in mind we have essentially described the application of an unweighted, multiple span, moving binomial test to identify REBs.
For each dataset, we calculated a global average proportion of mismatching reads, and used the binomial test to identify stop codon nucleotides whose individual proportion of mismatches significantly deviated from the corresponding global average.
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In an attempt to account for the effects of biological variability within our data, we chose a dispersion value of 0.3, which is between the recommended values as outlined in the edgeR user's guide [ 35] and applied exact negative binomial tests to identify differentially expressed genes.
In contrast, DESeq and edgeR estimate the means and variances of raw read counts under a negative binomial distribution and use exact tests to identify differentially expressed transcripts.
In contrast, DESeq, edgeR and EBSeq estimate the means and variances of raw read counts under a negative binomial distribution and use exact tests to identify differentially expressed transcripts.
This study introduces a formal statistical test known as the "C test" to determine when there is a need to apply the beta-binomial test instead of the binomial test to screen a roadway network.
We used an exact binomial test to examine the significance of overlap between LRES or LREA regions and earlier or later domains.
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