Sentence examples for binds with significant affinity from inspiring English sources

Neither of these two second messengers binds with significant affinity to the lipid-binding hSH3C domain of ADAP (data not shown).

In contrast to the latter, BMF binds with significant affinity to a subset of BCL-2 family members (BCL-2, BCL-xL, and BCL-w) (Chen et al., 2005; Kuwana et al., 2005), yet it clearly contributes to the apoptotic response to erlotinib.

The working hypothesis that underlies the computational study reported here is that ligands that bind with significant affinity to all three cloned opioid receptors, δ, μ, and κ, but with different combinations of activation and inhibition properties at these receptors, could be promising behaviorally selective analgesics with diminished side effects.

Although unable to bind prazosin with significant affinity, Myc-D125Aα1b-adrenoceptor-Y67C-eYFP was expressed to similar levels as Myc-α1b-adrenoceptor-Y67C-eYFP.

CAP70, CFTR-associating protein 70, has 4 PDZ domains and 3 of those domains bind CFTR with significant affinity in the order, 3 > 1 > 4.

Among the 9 peptide substrate candidates, we identified one peptide with sequence GWLYEIS can bind with Ydj1 with significant affinity (Fig. 1, Table 2).

We therefore propose that a DNA dye that substantially relies on electrostatic interaction for its DNA binding may not be ideal for qPCR application because such a dye may bind to ssDNA with significant affinity and is thus more likely to interfere with the chain extension step.

The binding assays revealed that all of the identified peptides bound to IAb with significant affinities in the range of 34 – 1858 nM (Table 2).

In contrast to the low binding affinity reported for the binding of LG100754 to RARα [14], we show that this ligand binds to RAR with a significant affinity.

As expected, the CrPV IRES did not bind to PTB1 with a significant affinity (Fig 8).

The PX domain of p47 phox binds with highest affinity to phosphatidylinositol 3,4-bisphosphate [PtdIns 3,4 P2], and with lower but significant affinity to PtdIns 3,4,5 P3, PtdIns 3,5 P2 and PtdIns(3 P [ 23- 25].