Sentence examples for binds with micromolar affinity from inspiring English sources

In an attempt to obtain specific IgE antagonists, we have designed and prepared a polypeptide named IgE-Trap that partially reproduces the IgE receptor-binding sites and binds with micromolar affinity to soluble IgE.

We show that a peptide comprising the first 25 amino acid residues of the CCR5 N-terminal domain and sulfated at the Y10 and Y14 side-chains binds with micromolar affinity exclusively to the monomeric form of RANTES.

MS2 bound with micromolar affinity to Bcl-xL, Bcl-2, and Bfl-1 and bound in the hundred-nanomolar range to Bcl-w.

In contrast to CML (CEL -modified proteins, whiCEL -modifiedt at submicromolar concentrations in human proteinsnd bind whichmicromolareaffinity, MG-Hs and MG-H-modified presents ate presubmicromolarmolar concentrations and bind to thumandomain with nanomolar affinity.

Each peptide was analyzed by SPR against immobilized AKT1 and the individual peptides bound AKT1 with micromolar affinity (Kd∼2 to 20 µM).

Goblin1 co-crystallizes with OGT, revealing an ordered C3 linker and retained substrate-binding modes, and binds the enzyme with micromolar affinity, inhibiting glycosyltransfer on to protein and peptide substrates.

This interpretation is consistent with the observation that RsTSPO binds both PK11195 and PpIX with micromolar affinity, while HsTSPO has nanomolar affinity for PK11195 but has an affinity for PpIX similar to that of RsTSPO.

Simple benzoic acid derivatives bearing an aliphatic 'tail' bind in the hydrophobic tunnel with micromolar affinity despite the lack of a glucosamine ring like that of the substrate.

We also demonstrated that FbpABp binds ferric complexes of ALC, ENT, DFB, and FC, all with micromolar affinity, and characterized those binding interactions in solution.

This modified peptide HBS3 binds the GDP-bound form of Ras with micromolar affinity and is capable of inhibiting the nucleotide exchange by Sos in vitro and in cell culture.[ 409] Hydrocarbon peptide stapling was used to stabilize an α-helix of the Rab6-interacting protein, an effector of Rab GTPases.

ITC studies revealed that CHOPS binds to the doubly sulfated C5a-receptor mimic C5aR7 28S2 with micromolar affinity (Kd = 3.6 ± 0.2 μM).