Sentence examples for binds with lower affinity from inspiring English sources
This implies that target 5' XXXGGGXXX 3' binds to the same ZFP with higher binding affinity in comparison to the target 5' XXXGTAXXX 3' which binds with lower affinity to the same protein [ 30].
Kaiso is actually bimodal in that it also binds with lower affinity to a conventional DNA motif [55].
These data are in some agreement with our in vitro binding assays but as compared to the non-phosphorylated Atx1 ULM, the phosphorylated peptide binds with lower affinity.
Follistatin also binds with lower affinity to other TGF-β superfamily members including growth and differentiation factor 9 (GDF9), myostatin and BMP 2, 5, 7 and 8 [ 24].
It also binds with lower affinities to a non-poly(A) cis-acting dendritic localizer sequence in the vasopressin mRNA [43], [44], [45].
Ligands that bind stably to G-protein uncoupled PTH1R [e.g. PTH (1-34)] produce a greater cAMP response for extended times after initial binding than ligands that bind with lower affinity [e.g., PTHrP (1-36)].
Glycine substitution of this residue destroyed binding to this site, whereas notably, TtgR has a second "general" binding site to which phloretin and other drugs bind with lower affinity, which is not dependent upon charged residues (29).
Inhibitor binding assays showed that both of the thermostabilised SERT mutants bound [125I]RTI55 (β-CIT) with affinity similar to that of the wild-type transporter, although cocaine bound with increased affinity (17- to 56-fold) whilst ibogaine, imipramine and paroxetine all bound with lower affinity (up to 90-fold).
Strikingly, 45% of the peaks (62/138) contain a chCaRE sequence that we predict would bind with high affinity to CaRF, while an additional 19.5% (27/138) have sequences that we predict would bind with lower affinity.
Importantly, it cross-reacted with the mouse peptide although it is bound with lower affinity to the Aq molecule than the corresponding rat peptide.
