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Full-length Acrp30 binds with highest affinity to AdipoR2, which is most abundant in liver (Yamauchi et al, 2003a).
αvβ3 integrin functions as an adhesion receptor on the surface of cells and binds with highest affinity to the extracellular matrix (ECM) ligand vitronectin (VN).
The gAcrp30 binds with highest affinity to AdipoR1, which has previously been shown to be expressed by a number of tissues including, brain, heart, kidney, liver, lung, spleen, and skeletal muscle (Yamauchi et al, 2003a).
ConA binds with highest affinity to oligomannose and hybrid glycans containing a Manα1-3(Manα1-6 Manα1-motif and less well to coManα1-6 Manα1-motifype structures (Brewer and Bhattacharyya, 1986).
The PX domain of p47 phox binds with highest affinity to phosphatidylinositol 3,4-bisphosphate [PtdIns 3,4 P2], and with lower but significant affinity to PtdIns 3,4,5 P3, PtdIns 3,5 P2 and PtdIns(3 P [ 23- 25].
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Thus, as with the SPR-derived binding results, WW2 was shown to bind with highest affinity, closely followed by WW3.
Specific binding experiments revealed that RvD1 binds with high affinity (Kd = 0.2 nM) to human neutrophils.
These data together suggest that NLX binds with high affinity to FLNA with the binding site located at FLNA2561 2565.
This agent binds with high affinity and specificity to the cysteinyl leukotriene binding sites.
Here we show biochemically that Hsp70 binds with higher affinity to expanded PABPN1 in vitro, and that binding affinity is proportional to the length of the polyalanine stretch.
In vitro evaluation showed that the conjugate binds with high affinity to SUR1.
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