Sentence examples for binds with high specificity from inspiring English sources
The chlorotoxin (CTx) is a scorpion-derived peptide, which binds with high specificity to glioma cell surface as a specific chloride channel and matrix metalloproteinase-2 blocker.
A trimeric complex (nuclear factors YA-C (Y-box binding factors)), forming a highly conserved, ubiquitously expressed transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes.
This complex binds with high specificity to DNA damaged by UV, is absent in a subset of xeroderma pigmentosum group E cells, and is required for global genomic repair of UV-induced damage.
By antibody phage-display, we have developed a human monoclonal antibody fragment (single-chain Fragment variable, scFv) that binds with high specificity and affinity to the fully processed mature form of human VEGF-C.
Although MAG, as lectin, binds with high specificity to α2,3-linked sialic acid residues, this feature does not seem to play a role for conferring inhibitory activity as demonstrated with a MAG mutant, MAG R118A, that has lost its affinity to sialic acid but is still inhibitory to CGN [3].
The light chain binds with high specificity to the soluble N-ethylmaleimide-sensitive fusion (SNARE) attachment protein receptors essential for exocytosis of acetylcholine.
Aptamers are modified nucleotides composed of single-stranded nucleic acids that adopt a specific three-dimensional conformation, allowing them to bind with high specificity and affinity to molecular targets in a manner similar to that of monoclonal antibodies.
The ligand patterned surfaces were shown not only to bind with high specificity to anti-DNP immunoglobulin E (IgE), but also to induce specific cellular responses when incubated with rat basophilic leukaemia mast cells [120].
As shown in Figure 1B and Figure S1, in the presence of Mn2+, Fur dimers bound with high specificity and affinity to PhilD, with an apparent binding constant (KDapp) of about 4.5±1.5 nM, defined as the protein concentration necessary to complex 50% of labeled DNA.
An important component of all of these therapies is the design of antibodies that specifically target specific cancer epitopes, and much of the ongoing research into cancer antibody therapy is focused on the engineering antibodies that bind with high specificity.
