Whereas EVTs bound with great affinity to all α integrin subunits (Figure 6B), LacZ-expressing JEG-3 cells failed to bind to α1, α4, and αv antibodies (Figure 6B).
This showed evidence of allele-specific binding for only one SNP, predicting that BRCA1 binds with greater affinity to the associated G allele of rs1150793 (ACAAGAC) (score 6.4) (relative profile score 90.4%).
Unlike 17β-oestradiol, which displays relatively equivalent binding on both ER subtypes, and raloxifene, which binds with greater affinity to ER-α, genistein aglycone binds selectively to ER-β over ER-α, from 7- to 48-fold, depending on the assay system employed (Kuiper et al., 1997, 1998; Barkhem et al., 1998; Hsieh et al., 2006).
Globally, the biological role of CRP after binding to ligands is to trigger the complement pathway [ 7] CRP binds with greatest affinity to phosphocholine residues, and with less affinity to native and modified lipoproteins [ 44], damaged cell membranes, a number of phospholipids, small nuclear ribonucleoprotein particles, and apoptotic cells [ 45].
In contrast, NADH binds with greater affinity than NAD+ by a factor of 6 (Table 2).
GBR-12909 selectively inhibits DA uptake and binds with greater affinity to the dopamine transporter than cocaine.
This approach is based on the concept that target DNA that perfectly matches its probes binds with greater affinity than one with a mismatch.
Finally, the QSAR models were applied to the design of a peptide to bind with greater affinity than the known binding peptide sequences of the yRSP5-1 WW domain.
Adsorption and displacement results agreed, indicating relatively high MW SRHA constituents bound with greatest affinity.
However, this relationship does not always hold true; cis-permethrin and fenvalerate interact with both closed and open sodium channels, but they bind with greater affinity to the open state (Forshaw et al. 2000; Cantalamessa 1993).
