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AMD3100 is a bicyclam molecule with an aromatic bridge[21], and binds with extreme specificity to CXCR4, with contacts at amino acid positions 171, 182, 193 and 262 of CXCR4.
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It is an intoxicating process to reimagine the world as it pleases you, and then will it into physical existence with extreme specificity, without compromise.
The complex consists of large sheds interspersed with functional courts and alleys, as in a Hollywood film lot, punctuated with sets of extreme specificity.
Adaptive immunity provides defense mechanisms ensuring extreme specificity for foreign antigens with virtually unlimited diversity.
In particular, parasites displaying host alternation may show extreme specificity and adaptations for two very distantly related hosts with few features in common [ 1].
The extreme specificity of these exquisite costumes grounds the otherwise fantastical show.
A second characteristic of enzymes is their extreme specificity.
Remarkably, tetrapeptides containing pSXXF motif bind with high specificity and micromolar affinity.
Successful inhibitor design requires a region where small molecules or peptides can be bound with high specificity.
Second, there are very few antibodies that bind with sufficient specificity to phospho-VEGFR-2.
As expected, 8WG16 bound with relative specificity to unphosphorylated or singly phosphorylated CTD peptides.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com