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As to the infection of a permissive host cell, CVB3 mainly binds to two specific cell surface receptors, the coxsackievirus and adenovirus receptor (CAR) or the membrane protein decay accelerating factor (DAF).
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TNF- α can bind to two specific receptors: TNFR1, with an intracellular death domain, and TNFR2, with a higher affinity and mostly involved in neuroprotection [ 42].
VEGF-soluble proteins bind to two specific tyrosine-kinase receptors, VEGFR-1 (flt-1) and VEGFR-2 (flk-1/KDR), which are expressed preferentially in endothelial cells.
For typical affinities and concentration values, the average number of Ste5 bound to one specific kinase is 19 while the average number of Ste5 simultaneously bound to two kinases is 0.19 (and 0.0019 for three kinases simultaneously bound).
Adiponectin binds at the cellular level to two specific transmembrane receptors, adiponectin receptor 1 (andpoR1) adiponectinctin receptor 2 (AdipoR2) [ 14, 15], which provokes an intracellular activation of the 5'-AMP-activated protein kinase (AMPK) and PPAR-alpha [ 16].
S1P binds mainly to five specific G-protein-coupled receptors (GPCRs), S1P1−5 [ 38].
In addition, a c-kit2 specific antibody, designated hf2, binds to two different G-quadruplexes formed in Sp1 sites.
Corticosterone binds to two types of receptors.
The ligand TRAIL binds to five receptors.
Researchers have long known that these proteins bind to DNA in a modular fashion, with each "finger" recognizing three to four specific nucleotides.
Select one to three specific locations.
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