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It binds to two different DNA binding sites [70] and our depiction of its enhanced binding to its element in the presence of TNFα suggests that it might be critical in the TNFα action in HepG2 cells.
Atomic resolution crystal structure of a complex between mGRFT and nonamannoside revealed that a single mGRFT molecule binds to two different nonamannoside molecules through all three carbohydrate-binding sites present on the monomer.
Angiotensin II is a potent regulator of cardiovascular homeostasis and binds to two different G-protein-coupled receptors.
The stopped-flow studies revealed that methotrexate binds to two different conformations of the enzyme, and the association and dissociation rate constants were determined.
Angiotensin II, a potent regulator of blood pressure and of water and electrolyte balance, binds to two different G-protein-coupled receptors.
Among various integrin receptors, the α4β1 integrin receptor binds to two different ligands, the endothelial cell surface protein vascular cell adhesion molecule-1 (VCAM-1) and the extracellular matrix component fibronectin (Mould et al. 1994).
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It has been reported that α4β1 integrin binds to three different site of fibronectin (Mould et al. 1994).
As mentioned previously, JMJD2A-tudor recognizes and binds to four different methylated peptides: H3K4me3, H3K9me3, H4K20me2 and H4K20me3.
Figure 3 shows how a single region of p53 binds to four different partners.
TRAIL binds to five different receptors, of which only two are capable of inducing apoptosis, DR4 and DR5.
TRAIL binds to five different receptor types that all belong to the TNFRSF receptor family: TRAILR1 to TRAILR4 and osteoprotegerin (OPG).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com