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EPO "classically" binds to two EPORs, which become joined as a homodimer and change.
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However, several groups of investigators subsequently demonstrated that C-20 produces false-positive signals because it binds to non-EpoR proteins.
When the Epo hormone binds to the EpoR receptor, the receptor's cytoplasmic domain is phosporylated, which creates a docking site for signalling molecules, in particular STAT5.
CEPO: The administration of carbamylated EPO (CEPO), which does not bind to the classical EPOR, also provides renal tissue-protective effects.
For example, carbamylated EPO (CEPO) does not bind to the classical EPOR isoform and is devoid of hematopoietic activity; however, it can provide tissue protection in the kidney, supporting the existence of a heteroreceptor EPO isoform, which mediates tissue protection [27].
Like endogenous Epo, ESAs bind to and activate EpoR on erythrocytic progenitors (colony-forming units erythroid) in bone marrow (Broudy et al, 1991).
For example, carbamylated EPO CEPOO) does not bind to the classical EPOR isoform and is devoid of hematopoietic activity; however, it can provide tissue protection in the kidney, supporting the existence of a heteroreceptor EPO isoform, which mediates tissue protection [ 27].
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