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The N-terminal domain has an ATP-binding site, and natural products such as geldanamycin and radicicol binds to this domain.
FAD binds to this domain, near the N-terminal end of α1 and the carboxy ends of the strands β4 and β5.
An obvious candidate for the location of binding sites on VAMP7 for membrane traffic machinery is the longin domain, especially given the observation that AP3 binds to this domain (Martinez-Arca et al., 2003a, 2003b), as well as the demonstration that the regulatory Habc domain of the SNARE vti1b binds to the clathrin adaptor epsinR (Hirst et al., 2004; Miller et al., 2007).
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The results also provide evidence for RNA exit in the vicinity of the carboxyl-terminal repeat domain, coupling synthesis to RNA processing by enzymes bound to this domain.
The third EH domain displays a different specificity: FW containing motifs preferentially bind to this domain.
Since the C-terminal PDZ ligand domain is essential for inducing LTD, we considered molecules known to bind to this domain.
Interestingly, some nuclear import receptors also bind to this domain (Shah et al, 1998; Ben-Efraim et al, 2009) but relevance of these interactions in the context of Tpr's NPC attachment still remains unclear.
TNFR1 contains a cytoplasmic death domain and when unstimulated, this domain binds to the death domain of the protein SODD (silencer of death domain).
In addition, studies by the Tedder laboratory have demonstrated that the CD22 ligand binding domain is required for in vivo B-cell survival [ 33], which could explain why anti-CD22 mAbs that bind to this ligand-binding domain have greater efficacy than anti-CD22 mAbs that bind to non-ligand-binding domains.
This SH2 domain binds to the helical domain when PI3K is inactive, but is released from the helical domain when a competing SH2-binding site becomes available in growth factor-stimulated cells; these competing SH2-binding sites are phosphorylated tyrosines of activated growth factor tyrosine kinase receptors (Miled et al, 2007).
In this state, Ras binds to a domain of c-Raf kinase referred to as the ras-binding domain (RBD).
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