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TlL binds to these interfaces in an active or open form, thus implying a displacement of the helical lid away from the active site.
The interfacial activation is not supported by zwitterionic vesicles or by large anionic vesicles of 100 nm diameter, although TlL binds to these interfaces.
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In the past 5 years, there has been remarkable progress in identifying small molecules that bind to these interfaces.
Owing to the characteristics of PPI targets, the small molecule term is a generic name to refer to synthetic molecules and small peptides that bind to these interfaces.
One c-di-GMP binds to the interface of STING dimer with a unique mode.
For example, in two cases, interleukin-2 (PDB: 1m49) and acetyl-CoA carboxylase (PDB: 1w96), the ligands bound to the interfaces of protein protein interactions.
Therefore, if the Gibbs energy of the peptide bound to the interface decreases when binding improves, we would expect the transfer to the bilayer interior from the interface to become more unfavorable, which would slow down translocation and efflux.
Specific inhibitors that bind to the interface of DNA-Top complexes can stabilize Top-mediated transient DNA breaks.
where depending on the model, is either a bulk penetration depth of states bound to the interface at z = z 0 or a thickness of the interface, see [24].
STA-21 is a small molecule inhibitor of Stat3 identified through virtual ligand screening of compounds that bound to the interface of Stat3 Shomodimersers [17].
While most modulators can only bind to one position with a one modulator per dimer ratio, some thiazide-based modulators can bind to the interface in two symmetrical positions with a two modulator per dimer ratio.
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