Sentence examples for binds to the unique from inspiring English sources
Here, we report that ethaselen, a novel organoselenium compound with anticancer activity, specifically binds to the unique selenocysteine cysteine redox pair in the C-terminal active site of mammalian TrxR1.
It has previously been reported that Nck binds to the unique domain of Lck via its SH3 domains, and that phosphorylation of Ser disrupts the interaction [ 23].
Although it is difficult to unambiguously prove that a ligand is a H2O/OH− molecule using crystallography, our assignment is consistent with electron−nuclear double resonance (ENDOR) studies of MtCODH, which indicated that H2O/OH− binds to the unique Fe (40).
What is clear at this stage for radical SAM enzymatic reactions is that SAM binds to the unique iron of the [4Fe 4S] cluster via a classical chelate formation using the amino and carboxylate moieties; Inner-sphere electron transfer from the cluster to SAM initiates S C bond cleavage to generate the dAdo intermediate also found in B12 radical reactions.
SAM binds to the unique iron of the [4Fe 4S] cluster as had been previously demonstrated via ENDOR spectroscopy, and it packs close to the peptide substrate such that the C5′ of SAM is only 4.1 Å from the α-C of Gly734 where the H-atom is abstracted during PFL activation.
All amide moieties of the bengamide derivatives bind to the unique shallow cavity and interact with a flat surface created by His-212 of MtMetAP1c in the Mn II) form.
Regulatory proteins bind to the unique carboxy termini of the PP1 isoforms to direct their isoform specific activities.
The resulting native structure shows H2O/OH− bound to the unique iron of the C-cluster and no bridging sulfide, despite the absence of CO.
In our native structure, a positive Fo − Fc electron density peak greater than 4σ is present, indicating a ligand bound to the unique Fe of the C-cluster.
Further, a base may not be necessary for the first deprotonation, as the p Ka of the water molecule may be dramatically lowered in its distinctive environment, bound to the unique Fe of the C-cluster.
