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TGFβ signals through type I and type II receptors when TGFβ ligand binds to the type II receptor.
IFN-β binds to the type I interferon receptor (IFNAR), an event that initiates the activation of the associated Janus kinases.
After IFN- γ binds to the type II IFN receptor, JAK1 and JAK2 are activated and subsequently phosphorylate only STAT1.
Pan1 also binds to the type I myosins Myo3/5 and facilitates their ability to stimulate Arp2/3 complex (Barker et al. 2007).
Activin A primarily binds to the type 1 receptors ALK4 or ALK7 in complex with ACVR2A or ACVR2B, causing activation of SMAD2 or SMAD3 [ 7].
TGF-beta binds to the type II receptor, recruits and phosphorylates the type I receptor and subsequently activates its receptor Smad, Smad2 or Smad3, by phosphorylation [ 21].
Similar(48)
Considering that a PDZ protein GRIP1 binds to the type-II PB motif of the GluR2 [ 37, 52, 57], it is expected that DTWD2 also binds to GRIP1.
ACTH then binds to the type-2 melanocortin receptor (G-protein receptor) at the level of the adrenal cortex to increase CORT release via cAMP-dependent mechanisms.
On the other hand, GIPC, a glut1-binding protein, has been found to bind to the type I PDZ domains of both α6A and α6B, the interaction being stronger on α6A (27).
The TGF-β family members bind to the type I and type II serine/threonine kinase receptors on the cell surface.
Type I IFNs comprise IFN-α, IFN-β, IFN-ε, IFN-κ and IFN-ω, which bind to the type I IFN heterodimeric receptor complex of IFN-α receptor 1 (IFNand) and receptor 2 (IFNAR2) (Chen et al., 2004).
More suggestions(18)
binds to the transmembrane
binds to the part
binds to the adrenomedullin
binds to the tail
binds to the target
binds to the concave
binds to the promoter
binds to the receptor
binds to the interface
binds to the cytokine
binds to the mu
binds to the acidic
binds to the plastic
binds to the drug
binds to the α4β2
binds to the prototype
binds to the adaptor
binds to the bile
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