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For human serum albumin, the combined output from the 300,000 low-resolution and 30,000 high-resolution quaternary structure models and 10 TX-MS identified inter-protein XL peptides supports three separate models where serum albumin binds to the three conserved C-repeats of the M1 protein (Fig. 3d 15,20.
Previous work has shown that TRF2 binds to the three telomere repeats within the DS region of OriP [21], [22].
Indeed, SAP97 binds to the three COOH-terminal amino acid residues of Kv1.5 channels, and coexpression of SAP97 and Kv1.5 channels increased IKur and 4-aminopyridine (4-AP) sensitive voltage-dependent currents in heterologously expressed cells (Murata et al., 2001; Abi-Char et al., 2007).
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Fibrinogen binds to the two B-repeats on the M1 protein, with slight differences in amino acid composition.
The structures also revealed that abacavir binds to the two amino-acid residues that are unique to the HLA-B*57 01 HLA-B*57 01hereby explaining the drug's allele specificity.
If AST is present, it binds to the two chemicals, causing a reaction that ultimately releases sulfite ions, SO3. 4. The next layer contains a methyl dye that is normally blue but turns colorless when sulfites attach to it.
EMSA and ChIP assay showed that OsSND2 binds to the two SNBE sites (Fig. 3e, f and Additional file 2: Figure S2).
Activation of PKA occurs when cAMP binds to the two regulatory subunits of PKA resulting in the release of the two catalytic subunits [25], [26].
Biochemical assays with purified components have shown that GalR binds to the two operator sequences, OE and OI, (Fig. 1) with equal affinity [3], [4].
RAD51 directly binds to the six conserved BRC repeats of BRCA2 (Chen et al, 1998, 1999).
Novobiocin is an antibiotic that binds to the two C-terminal ATPase sites of the Hsp90 homodimer.
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