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Previous work has demonstrated that βTrCP isoforms possess multiple WD40 motifs at their C-terminus, which fold into a target-recognizing phosphate-binding pocket [ 20]. βTrCP binds to the target proteins after they are phosphorylated at two residues located four amino acids apart within a phosphodegron motif.
However, in this case, the authors used a catalytically dead Cas9 mutant (dCas9), which still binds to the target and was shown to block RNA polymerase (RNAP) binding during either transcription initiation or elongation.
The E2 protein exists in solution and binds to the target DNA as a dimmer, whereas the C-DNA-binding domain consists of a dimeric β-barrel structure with a pair of symmetrically disposed α-helices that bind and bend the DNA [ 39].
Some radioligands may produce radiometabolite(s) that binds to the target receptor.
PRC1 binds to the target sites through PREs, and PREs may be ncRNAs or proteins, such as Jarid2, KDM2B and HOTAIR (Schwartz and Pirrotta, 2013).
The Raman signal intensity is from a cyanine dye 3 (Cy3) modified aptamer 2 (apt 2), which binds to the target the same as SiO2@Au-apt 1.
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The conclusion was that MYC actually requires certain modifications to bind to the target E box and that binding is a signal for further modifications.
concentration of drug specifically bound to the target.
Next, GSH-bound PrfA will bind to the target DNA to regulate gene transcription.
UV spectrophotometry was used to determine whether liposomes were successfully bound to the target ICAM-1 antibodies.
Naturally, a dissociation approach requires a set of ligand copies bound to the target.
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ions to the target
binding to the target
binds to the endothelium
binds to the pocket
binds to the receptor
binds to the transmembrane
binds to the peptide
binds to the carboxyl
binds to the metal
binds to the transcription
binds to the core
binds to the iron
binds to the signal
binds to the hypoxia
binds to the biotin
binds to the histone
binds to the type
binds to the insulin
binds to the protein
binds to the tumor
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