Killer cells, which may be either cytotoxic T cells or natural killer cells, have receptors that bind to the tail portion of the IgG antibody molecule (the part that does not bind to antigen).
The Myo Va motor complex includes two heavy chains, 12 calmodulins that bind to the neck region, and a dynein light chain 2 [10], and calmodulin kinase II, both of which bind to the tail region [11], [12].
The C-terminal residues of τ500 (residues 622 643: not modeled) bind to the tail of the polymerase, while the globular domain of τ500 binds to the polymerase fingers domain (see Figure 2 figure supplement 2 for more details).
A fraction of SP immediately circulates systemically by entering into the hemolymph [ 8], whereas another fraction remains bound to the tail of sperm and is thought to be gradually released into the hemolymph by cleavage [ 9, 10].
The activated form of vinculin primarily localizes to FAs [ 17] where the binding sites for its many partners, including talin and α-actinin (which bind to the head domain), VASP, vinexins, ponsin, and Arp2/3 (which bind to the neck region), and paxillin, F-actin, and PIP2 (which bind to the tail domain) are exposed [ 18].
Class I myosins might act as multifunctional linkers between the actin filaments that interact with the motor domain and the plasma membrane, and membrane-associated protein complexes that bind to the tail domain (Arif et al., 2011; Bi et al., 2013; McConnell and Tyska, 2010).
Outside-in signaling by αIIbβ3 is positively regulated by talin, which physically binds to the β3 tail through a phosphotyrosine binding domain (PTB) [19], and Src [12].
Since AKAP150 also binds to the carboxyl tail of Cav1.2 via leucine-zipper motifs, it is postulated that AKAP150 binds to the C-terminal tail of Cav1.2-LQT8, thereby facilitating longer channel openings and interaction between multiple Cav1.2-LQT8 channels to increase the frequency of "coupled gating"; consequently, greater Ca2+ influx leads to intracellular Ca2+ overload.
