Several lines of evidence suggest that anandamide binds to the same binding site of the TRPV1 receptor as capsaicin [45].
To determine whether Stat3 binds to the same binding sites in CLL cells as in MM1 cells, we used the ChIP assay.
We chose to use muscimol as an agonist because it is a potent GABAA receptor agonist that crosses the placental barrier and it binds to the same binding pocket on pentameric GABAA receptors as GABA [36], [37].
The target specificity of 64Cu-DOTA-knottin 3-4A was measured by blocking studies using an unlabeled integrin binding peptide (c RGDyK)) that binds to the same epitope on the integrin receptor.
Moreover, we found that SGTP binds to the same binding motif (i.e., the HRD motif) in these CDKs as ATP.
However, there are also many instances wherein a given ligand binds to the same or homologous protein in different binding environments.
Overlapping protein binding is observed in the enhanceosome where the ATF-2/c-Jun heterodimer binds to the same DNA base pairs as the IRF-3 protein.
Like LMB, ratjadone covalently binds to the same cysteine residue of CRM1 and inhibits the cargo protein binding to CRM1 (Meissner et al. 2004).
Tasimelteon mimics melatonin and binds to the same receptors.
Omontys is not EPO, but binds to the same receptor in the body.
This peptide binds to the same cell-surface receptors used by Plasmodium to recognize and invade mosquito cells.
