Herceptin binds to the part of Her-2 that juts out, preventing the protein from being activated.
This protein recognizes and binds to the part of a cargo molecule called a 'nuclear export signal', and the Crm1 protein also binds to another protein called RanGTP.
Unfortunately, stem-loop RT-PCR does not allow the user to control the specificity of the reaction by melting curve analysis and the TaqMan probe does not contribute to specificity as the probe binds to the part of the cDNA sequence that originates from the RT primer.
The hormones bind to the part of the proteins (known as the extracellular domains) that are on the outside surface of cells.
Thr208, Lys210, Lys214, and Arg215 bind to the parts of the dsRNA major groove directly beneath them.
To develop novel immunofluorescence-labeling and antigen-detection systems, the ZZ domain derived from Staphylococcus aureus, which binds to the Fc part of immunoglobulin G, and enhanced green fluorescent protein (EGFP) were displayed on the cell surface of Saccharomyces cerevisiae by cell-surface engineering using the C-terminus 318 amino acids of Flo1 protein.
When a ligand binds to the extracellular part of Notch, this causes the receptor to break in two.
TRAF6 adaptor protein binds to the intracellular part of the activated RANK receptor and starts the NF-κB pathway, which finally leads to activation of osteoclastogenesis [ 22].
We propose that PEG-PPB-IFNγ is taken up via PDGFRβ and the internalized construct next releases IFNγ or its metabolite, which then binds to the intracellular part of IFNγR1 and activates the JAK/STAT pathway.
It is well established that solvent-exposed hydrophobic surfaces are formed upon Ca2+ binding to CaM, and ANS binds to the hydrophobic parts of proteins through polar interactions and can be monitored by the increase in fluorescence emission intensity, which demonstrates the activity of Ca2+/CaM indirectly [21].
This shows that when exposed to light, the light-sensing part of the photoreceptor, called LOV domain, detaches from the DNA binding part and binds to the LOV region of a second molecule.
