Sentence examples for binds to the mutant from inspiring English sources

Possibly, p53 binds to the mutant Brca1 protein, which still contains the p53-binding domain.

In these systems, the small molecule binds to the mutant receptor and activates expression of a target transgene.

There is very little difference in the way (3 R,4 R) - 2 binds to the mutant and wild type with the exception of the pyrrolidine moiety.

As a result of these conformational changes both Gln96 and Arg60 are forced to readjust position when IPP binds to the mutant enzymes.

From Table 3, when TP5 bound to the mutant DR11, the binding energy had a slight change; however, Ala11 completely lost its role as a binding site.

Whereas, when TP5 bound to the mutant DR62, the binding energy had a distinct change; Ala62 remained to exert a positive role as a binding site, suggesting that Asn anchor mainly contributed to the binding energy.

We found that c-Jun binds to the AP-1 DNA binding site following JSI-124 treatment whereas c-Jun failed to bind to the mutant AP-1 site.

Therefore, conformational rescue by means of chemical substances that bind to the mutant AGA precursor, stabilizing its structure and allowing correct folding and processing, appeared feasible.

The mutant retained specificity for ATP; ADP and GTP bound to the mutant with dissociation constants 16 and 53 μM, respectively.

Several mutant ligands in the ensemble are expected to bind to the mutant receptors, and then the ensemble may create a defensive wall surrounding the target receptors in receptor-sequence space.

The aim of this work was to synthesize and evaluate radiolabeled compounds that bind to the mutant IDH1 enzyme with the goal of enabling noninvasive imaging of mutant IDH1 expression in gliomas by positron emission tomography (PET).