Sentence examples for binds to the luminal from inspiring English sources
The ER-resident chaperone immunoglobulin heavy chain-binding protein (BiP) binds to the luminal domain of the ER stress sensors and keeps them in an inactive state.
After blood flow measurement, grafted kidneys were retrieved from NMRI nu/nu mice and subjected to immunohistochemical analysis using antibodies against insulin and BS-1 lectin which binds to the luminal surface of endothelial cells [34].
First, we examined if unfolded protein CH1 binds to the luminal domains of Ire1 and Perk.
When ticks feed and ingest blood, the hemoglobin liberated from lysis of the erythrocytes binds to the luminal surfaces of the midgut epithelial cells.
The establishment of functional blood flow in newly induced vascular structures was assessed by intravenous injection of fluorescently labeled tomato lectin, which binds to the luminal endothelial surface of vessels only if they are perfused by the systemic circulation (von Degenfeld et al, 2006).
To further compare the relative amounts of perfused vessels in C6 and HT1080 tumors, vessel perfusion was assessed by another method, namely i.v. injection of FITC-conjugated Lycopersicon esculentum tomato lectin (FITC-lectin), which binds to the luminal surface of blood endothelial cells (BECs, defined as CD31 positive) in functionally perfused vessels.
BiP is normally bound to the luminal domain of PERK and acts as negative regulator of activation [44].
To explore this possibility, we injected mice with Intralipid, which unlike heparin displaces only Lpl bound to the luminal surface of the endothelium [15], [31].
Consistent with our prediction, we found that BiP engaged with misfolded protein CH1, is unable to bind to the luminal domains of Ire1 or Perk.
Soluble components - that is, albumin, unbound hyaluronic acid molecules, thrombomodulin, and various serum proteins (for example, superoxide dismutase, antithrombin III, and cell adhesion molecules) - are bound to the luminal portions of glycocalyx [ 4].
NPC2 binds to the second luminal loop of NPC1, an event that may precede the cholesterol transfer to the NTD (Deffieu and Pfeffer, 2011).
