This may be particularly common for antibiotics that bind to the key sites on RNAP, where substitutions would give rise to growth defects.
DOI: http://dx.doi.org/10.7554/eLife.02046.009 Wdirectlyctly binds to the chromatin of key genes required for in ESC self renewal (Ang et al., 2011).
To confirm that ZFHX3 binds to the promoter of the key predicted target genes Avp and Vip in vivo, we performed quantitative ChIP on SCN tissue from Zfhx3 +/+ animals (ZT3) using ZFHX3 antiserum.
α-melanocortin-stimulating hormone (α-MSH), a postranslational product of the Pro-opiomelanocortin (POMC) gene, binds to the MC receptor on key structures in the central nervous system and triggers an anorectic signal [15].
For example, PAD4 binds to the promoter region of key stem cell genes such as Klf2, Tcl1, Tcfap2c, Kit, and Nanog, thereby activating their expression.
This is exemplified by the demethylase KDM7B, which binds to the promoters of several key cell cycle regulators, including E2F1 target genes, and is required for their transcriptional activation by removing the repressive H3K9me1/2 and H4K20me1 [ 179].
Their search turned up a suspect: a piece of a receptor for hypocretin resembles part of the H1N1 influenza nucleoprotein which binds to the virus genome and plays a key role in its replication.
CXCL12 binds to the widely expressed CXCR4 and regulates key aspects of development, stem cell motility and tumour metastasis to tissues with high levels of CXCL12.
After insulin is released from the β cell following a glucose load, it travels directly to the liver via the portal vein, where it binds to the insulin receptor and elicits two key actions at the level of gene transcription.
In rice, OsMYB61 is a key regulator that binds to the promoter of CESA genes and regulates their expression (Huang et al., 2015).
