Therefore, if the Gibbs energy of the peptide bound to the interface decreases when binding improves, we would expect the transfer to the bilayer interior from the interface to become more unfavorable, which would slow down translocation and efflux.
Specific inhibitors that bind to the interface of DNA-Top complexes can stabilize Top-mediated transient DNA breaks.
where depending on the model, is either a bulk penetration depth of states bound to the interface at z = z 0 or a thickness of the interface, see [24].
Traditional plasmonic materials usable in visible/near infrared range, noble metals, are unsuitable for uses in the THz regime due to low confinement to the metal; the wave is weakly bound to the interface, a phenomenon sometimes called the Zenneck plasmon [7].
STA-21 is a small molecule inhibitor of Stat3 identified through virtual ligand screening of compounds that bound to the interface of Stat3 Shomodimersers [17].
Several reports (Kuhn et al. 2013; Wang, Thijssen, et al. 2013) have proposed that pharmacological treatment is necessary to restore the function of the perturbed network as drugs often bind to the interface of the disease-associated proteins.
While most modulators can only bind to one position with a one modulator per dimer ratio, some thiazide-based modulators can bind to the interface in two symmetrical positions with a two modulator per dimer ratio.
Importantly, on the basis of related SF2 helicases, ATP was shown to bind to the interface of the RecA-fold subdomains and stabilize a 'closed' state (Sengoku et al., 2006).
Overall, our results from the present study show that the dimer interface should be considered a potential target for cancer treatment, where the identification of small molecules that bind to the interface of procaspase-3, resulting in its activation, may be a viable alternative to current therapies.
