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It has been shown that EGCG binds to the intercellular adhesion molecule 1 (ICAM 1) on the endothelium thus blocking the adhesion of Plasmodium infected erythrocytes [20].
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Ezrin and α-actinin bind to the intracellular domain of the intercellular adhesion molecule-2 (ICAM-2) [30], [30] and to actin.
Lymphocyte function-associated antigen-1 (LFA-1, CD11a/CD18, αLβ2), the most abundant and widespread in expression β2-integrin, binds to the membrane proteins termed intercellular adhesion molecules ICAM-1 to ICAM-5 [ 4, 8- 12].
Additional chemotactic molecules operate in blood vessels including sICAM-1 (soluble intercellular adhesion molecule 1), which binds to the CD11b/CD18 (Mac-1) integrin receptor and induces transendothelial migration of neutrophils [31].
IF2, bound to GTP, binds to the 30S P site.
Specifically, cyclosporine binds to the cyclophillin receptor.
LFA-1 binds to intercellular adhesion molecules (ICAM-1/2) expressed on the surface of endothelial cells and other leukocytes, while VLA-4 binds to the extracellular matrix component fibronectin and to vascular cell adhesion molecule-1 (VCAM-1).
The adherent cells are interconnected to each other and/or bound the cells to the intercellular matrix).
The integrin lymphocyte function-associated antigen (LFA -1 (CD11a/CD18) is expressed on activated T ceLFA -1d binds to interCD11a/CD18dhesisn molexpressedICAM-1) (CD54) fonnd on the surfactivatedny cell Types.
Genetic deletion and/or inhibitory antibody studies have shown that besides CX3CR1 [ 17], the patrolling behaviour of monocytes is also dependent on the integrin Lymphocyte Function-associated Antigen 1 (LFA-1;[ 16]), which binds to intercellular cell adhesion molecule-1 (ICAM-1) on endothelial cells [ 18].
Both aspects are mediated by integrins, heterodimeric cell surface receptors that bind to the extracellular matrix and have roles in intercellular adhesion as well.
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