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It binds to the growth hormone secretagogue receptor 1a (GHS-R1a), a class A G-protein-coupled receptor.
Under normal conditions, growth hormone (GH) is released from the anterior pituitary in the brain, binds to the growth hormone receptor (GHR) on the surface of hepatocytes, and this binding triggers a signalling cascade that leads to increased IGF1 synthesis by the liver for export to the blood.
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PRH can also bind to the growth control protein PML and translation factor eIF-4E to regulate cell proliferation.
sFlt-1 is soluble vascular endothelial growth factor (VEGF) receptor 1. sFlt-1 binds to the proangiogenic growth factors VEGF and placental growth factor (PlGF), thereby neutralizing their functions.
One of them is Tgfa, which is a growth factor that binds to the epidermal growth factor receptors (EGFR).
IGF2BP2 binds to the key growth and insulin signaling molecule insulin-like growth factor 2 (IGFII) and is highly expressed in pancreatic islets [3].
Panitumumab (ABX-EGF, Vectibix™, Amgen, Thousand Oaks, CA, USA) is a fully human IgG2 mAb that binds to the epidermal growth factor receptor (EGFR) with high affinity [21].
Secreted PCSK9 binds to the epidermal growth factor repeat A (EGF-A) region of the LDLR [ 21, 32, 179].
CCN2 binds to the epidermal growth factor receptor (EGFR) and triggers ubiquitination by inhibiting the formation of the β-pix/Cbl complex, resulting in the degradation of EGFR.
During patterning in Drosophila, developing oocytes produce the TGFα protein Gurken that binds to the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase (RTK) localized to the posterior follicle cells, to initiate RAS 1 signaling.
TGFA encoded by a gene mapped at 2p13, is a secretion protein that binds to the epidermal growth factor receptor (EGFR) and is situated at the palate epithelium during palate closing [ 13].
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