Sentence examples for binds to the first from inspiring English sources
We assume that the cooperative binding of the transcription factors causes pleiotropic mis-regulation at these targets (since the other transcription factor, which does not have a binding site at such sites, now binds to the first transcription factor through a physical interaction).
In light of the receptor mechanism suggested above for Asc enhancement of adrenergic function, and since Asc modifies dopamine binding to its receptors [1], [18] and binds to the first extracellular loop of the histamine receptor [4], it was logical to search for an Asc binding site on the AR that could act allosterically to modify receptor sensitivity.
Zhang and coworkers found that the C-terminal tail of X11α folds back and binds to the first PDZ domain, suggesting that the binding site of PDZ1 is closed [ 61].
We therefore considered the possibility that ATF4 binds to the first intron of VEGFA gene under ER stress conditions.
Dkk1 binds to the first EGF-like domain of Lrp5/6, with which also sclerostin and Wnts interact [34], [44].
A second MR antibody that binds to the first 18 amino acids of the receptor (rMR1-18 1D5) was compared with the original antibody, which binds between amino acid sequence 770 and 945.
For the group 2 NA N3, 3- p-tolyl)allyl-Neu5Ac2en binds to the second sialic acid binding site instead of the active site.
This mode of binding differs from the previous finding that LRRK2 binds to the second RING finger domain of the E3 ubiquitin ligase Parkin [32].
Immunoprecipitation and GST pull-down assays demonstrated that PRR7 binds to the third PDZ domain of PSD-95.
They are joined together at the other end by a third subunit, Scc1p, which also binds to the fourth subunit, Scc3p.
