Sentence examples for binds to the external from inspiring English sources

When J591 binds to the external domain of PSMA on LNCaP prostate cancer cells, the J591/PSMA complex undergoes endocytosis via clathrin-coated pits and accumulates in endosomes (3).

Indeed, cetuximab, a human-mouse chimeric IgG1 antibody binds to the external domain of the EGFR, has been approved by FDA in 2004 for the treatment of metastatic colorectal cancer [3].

One explanation for this would be if the inhibitor binds to the external surface of the transporter and then uses the normal translocation cycle to reach its final binding site.

AGE-coordinated Cu (II) almost certainly remains catalytically active, and could therefore bind to the external, high-affinity Cu (II -binding sII -binding near the NH2-terminusite CTR1 [ 79].

There the triglycerides are hydrolyzed to free fatty acids and glycerol through the action of the enzyme lipoprotein lipase, which is bound to the external surface of adipose cells.

This includes the IP address es) bound to the external interface of the ISA firewall.

Zn+2 bound to the external surface of vesicles was removed with ethylenediamine-tetraacetic acid.

The supports (ISRP-RAM phases A F) have an alkyl-chain (14 methylenes) with two embedded ureido groups bound only to the internal surfaces of the porous silica, and polyvinyl alcoholic groups (PVA, 100 000 → 22 000 molecular weight) chemically bound to the external surfaces.

The GPC5 gene encodes glypican 5, a member of the heparan sulfate preoteoglycans (HSPGs) that are bound to the external surface of the plasma membrane by glycosyl-phosphatidylinositol (GPI) linkage [25].

Monoclonal antibodies directly bind to the external domain of these TK receptors.

Free enzyme and enzyme bound to the external surface of the liposome are inactivated according to a first order kinetics.