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"It is usually assumed that the Shiga toxin binds to the endothelium and leads to swelling and clotting, obstructing the vessels," Gerloff says.
Comparisons with the specific endothelial cells used in this study also showed that almost twice as much CXCL12 binds to the endothelium when treated from below or basally compared to apically (Figure 2A) (p<0.05).
Following degranulation, MPO binds to the endothelium where it can potentially remove NO during peroxidase turnover.
Endotoxin also binds to the endothelium, proteins and circulating cells, and this reduces the plasma concentration; however, whether this interacts with the vasodilating effect of inhaled NO is not clear.
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This may affect the leukocytes in their ability to bind to the endothelium.
Parasitized erythrocytes bind to the endothelium directly through endothelial receptors and may indirectly bind through VWF and platelet complexes [23].
The mechanical hypothesis is based on the observation that mature infected red blood cells (IRBC) bind to the endothelium of the brain and other organs [7].
Since Lpl is rapidly cleared in the liver [32], [33], this technique may underestimate the amount of Lpl bound to the endothelium; nevertheless, the levels are significantly lower in Col18a1−/− mice compared to wild-type mice.
Presumably these differences reflect not only the amount of Lpl bound to the endothelium, but also the rate at which it transfers from the subendothelium to the lumenal side of the vasculature.
Although leukocytes can bind to the endothelium via VAP-1, their counter-receptors were for a long time unknown [ 13].
First, they do not mimic the complex biochemical interactions that occur when natural platelets interact with and bind to the endothelium.
More suggestions(18)
binds to the flour
binds to the transmembrane
binds to the part
binds to the hemeprotein
binds to the adrenomedullin
binds to the tail
binds to the target
binds to the concave
binds to the promoter
binds to the receptor
binds to the interface
binds to the cytokine
binds to the brain
binds to the guanylate
binds to the plastic
binds to the drug
binds to the α4β2
binds to the cyclophillin
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