Sentence examples for binds to the drug from inspiring English sources

We found that since vemurafenib binds to the drug binding site of human ABCG2 with relatively high affinity, it effectively inhibited ABCG2-mediated transport of other drug substrates.

LBVS requires at least one known active ligand that binds to the drug target.

In the second stage, after a period of time, IgG is produced, which binds to the drug to form an additional complex, which is an additional elimination pathway for the drug.

The desired drug-binding proteins bind to the drug on the affinity beads, while other proteins flow through the beads.

All 26 of the protein structures used here were derived from very long molecular dynamics simulations at 310 K on human Pgp without any ligand bound to the drug binding domains.

An ELISA based bridging assay was developed to detect and titer immunoglobulins present in serum that specifically bind to the drug.

They found that different flavone (acacetin, chrysin, apigenin, luteolin), flavonol (galangin, quercetin), and flavanone (naringenin, hesperetin) could displace warfarin and highlighted that flavonoids were powerful competitors for HSA and could bind to the drug site 1.

In the first stage the drug stimulates B cells to produce IgM, which does not directly bind to the drug but affects its clearance.

8 The SAP in amyloid deposits is tightly but reversibly bound to the insoluble amyloid fibrils and is therefore in equilibrium with the free soluble SAP that is available to bind to the drug.

The following summary will primarily focus on those non-COX-2 targets of celecoxib that are able to directly bind to the drug and thus appear to represent additional intracellular drug receptors.

This can complicate the selection of the appropriate dose in these patients because soluble antigen in the interstitial space and plasma can bind to the drug, limiting the amount of drug available to bind to the true pharmacological target, the membrane-bound receptor.