Sentence examples for binds to the conserved from inspiring English sources

Using this concept as a signal transduction mechanism for our immunoassay, we have engineered ampicillin resistant virions to display a dimer of the z domain from Protein A. This zz-domain selectively binds to the conserved heavy domain of IgG across various species.

The segment of U1-70K from aa 61-202 (underlined in Figure 1A), comprising a long α helix and an RRM domain, binds to the conserved stem-loop 1 (SL1) of the U1 snRNA (Kondo et al. 2015).

NMR studies show that a locostatin precursor binds to the conserved phosphatidylethanolamine binding pocket of RKIP.

The histone RNA-binding protein HBP/SLBP (hairpin-binding protein/stem-loop binding protein), an essential regulator of histone gene expression, binds to the conserved hairpin structure located in the 3′UTR (untranslated region) of histone mRNA and participates in histone pre-mRNA processing, translation and histone mRNA degradation.

Hsp90 is an ATP-dependent molecular chaperone that can be inhibited by compounds such as geldanamycin, which binds to the conserved N-terminal ATP binding pocket and blocks conformational changes required for molecular chaperone function [36].

The NICD is then translocated to the nucleus [14] [17] and binds to the conserved CSL (CBF1/RBPjκ, Su(H) and Lag-1) DNA-binding protein [18], [19], which is converted from a transcriptional repressor to activator.

In the case of the P450 proteins modeled for this study the top scoring ligand binding site predictions all included heme bound to the conserved iron binding cysteine.

The LasR-OdDHL and RhlR-BHL complexes bind to the conserved las-rhl boxes residing in the promoters of target genes, thereby activating their transcriptional expression (Schuster and Greenberg, 2007; Whiteley and Greenberg, 2001; Whiteley et al., 1999).

To test whether Stat92E can bind to the conserved 4 n sites in vitro, oligonucleotides containing these sites (known as 4 n Dome3 and 4 n Dome4; Fig 3A) were used in EMSAs together with a Stat92E GFP (green fluorescent protein) fusion protein activated by co-expression of the constitutively active Jak allele HopTuml (Luo et al, 1995; Karsten et al, 2006).

Co-IP analyses of these proteins with Ubr2 demonstrated that Ubr2 binds to the evolutionarily conserved N-terminal half but not the unconserved C-terminal half of Tex19 (Fig. 2B).

In higher eukaryotes, the majority of insulator elements bind to the highly conserved zinc-finger protein CTCF which has been shown to mediate diverse regulatory functions including promoter activation and repression, gene silencing, insulation, and imprinting [1], [2].