Sentence examples for binds to the closed from inspiring English sources

First, protamine binds to the closed channel and induces activation.

Mechanistic and structural studies indicate that erlotinib binds to the open, active conformation of HER1 kinase domain [ 58], while lapatinib binds to the closed, inactive conformation [ 55].

The structure showed that while Sba1 binds to the closed N-terminally dimerised Hsp90, locking the N-terminal domains together, it also simultaneously causes the release and stabilization of the middle domain catalytic loop in its active conformation.

This strongly suggests that Mg2+ can bind to the closed state.

It implies that ADP or NAD+ can only bind to the closed (Ca2+ inhibited) state.

Figure 11 does not intend to imply that ADP or NAD+ can only bind to the closed (Ca2+ inhibited) state.

Ye et al. found that TRIP13 binds to an adaptor protein that allows it to bind to the closed form of MAD2.

20) How does one know that Mg2+ can actually bind to the closed form; and that a re-open is not necessary for this to happen?

Binding of TBA to KcsA was very slow, whereas binding of Dauda was fast, suggesting that TBA can enter the cavity only through an open channel whereas Dauda can bind to the closed channel, presumably entering the cavity via the lipid bilayer.

At present, the most plausible model for how an SM might engage the tetrahelical SNARE bundle is derived from the crystal structure of Munc-18/nSec1 bound to the closed form of syntaxin, which folds into a tetrahelical bundle that might be a structurally analogous to the SNARE complex (Misura et al., 2000).

This demonstrates that the blocker must have already bound to the closed TREK channels before they were activated by the rapid mechano-gating mechanism, otherwise the initial amplitude for pressure activation in the presence and absence would have been very similar.