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The antibody has good biophysical properties, and it binds to the cells expressing the target antigen.
Berd and colleagues at the National Institute of Tumors in Milan, Italy, treated melanoma cells drawn from six patients with dinitrophenyl, a chemical that binds to the cells and serves as a red flag for the immune system.
Most of the TAT-pK/DNA complex binds to the cells 10 30 min after incubation.
Thus, our results indicate that riboflavin hydrolase strongly binds to the cells and reacts to riboflavin (see Fig. S2 in the supplemental material).
25 This soluble complex then binds to the cells that express GP130, and induces intracellular signal transduction and gene expression in the target cells.
The C. jejuni flgBC mutant was included as a negative control; this mutant binds to the cells at levels similar to that of a C. jejuni wild-type strain but is deficient in Cia protein secretion and delivery (not shown).
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We have shown that 7B2-PAC binds to the cell surface and is internalized, possibly localizing to ER and Golgi, within one hour.
Another monoclonal antibody, called Alemtuzumab (Lemtrada), which is used to treat chronic lymphocytic leukemia, also binds to the cell membrane of lymphocytes but works by stimulating antibody-mediated destruction of the cells.
Alcami, A., Symons, J. A. & Smith, G. L. The vaccinia virus soluble alpha/beta interferon (IFN) receptor binds to the cell surface and protects cells from the antiviral effects of IFN.
Verotoxin I (VT), an AB5 subunit toxin produced by enterohaemorrhagic Escherichia coli, binds to the cell surface glycolipid, globotriaosylceramide (Gb3) and is internalized into preendosomes.
After silver enters the cells, it binds to the cell wall and membrane and inhibits the respiration process [59].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com