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Thus, based on the results of this competitive DNA-binding assay, JDP2 binds to the ARE core (5′-TGACTCAGC-3′) of the complete ARE (−471 to −447) element.
The DNA binding sequence of Nrf2 and ARE sequence are very similar so that Nrf2 binds to the ARE sites leading to up-regulation of downstream genes.
Nrf2 binds to the ARE with high affinity only as a heterodimer with a small Maf protein, and the Nrf2/small Maf complex activates gene expression directly through the ARE [ 17].
When activated upon exposure to inducers, it dissociates from Keap1, translocates to the nucleus, complexes with other nuclear factors, and binds to the ARE of genes.
We next investigated whether Nrf2 binds to the ARE element on the HO-1 promoter after thrombin stimulation.
When activated upon exposure to inducers, Nrf2 dissociates from Keap1, translocates to the nucleus, complexes with other nuclear factors, and binds to the ARE of many Nrf2 target genes.
Similar(51)
The proteins that were bound to the beads were analyzed on SDS-PAGE.
Antibody bound to the wells was detected as described above.
Those expecting such thorough flash in "Dancer" are bound to be disappointed: the ride is somber, understated and chilling.
The financial implode is bound to be reflected in the movies that are being made, there's no question".
David Cameron, as the author of the referendum, was bound to be the de facto leader of Remain.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com