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OPP has been found to have estrogenic or anti-androgenic activity, and binds to the androgen or estrogen receptors [ 7].
Testosterone is produced by the testicular Leydig cells (LC) and binds to the androgen receptor (AR) to modulate gene transcription in target cells [4].
Testosterone binds to the androgen receptor in target tissue to mediate its effects.
Previous report indicated that EGR1 binds to the androgen receptor in prostate carcinoma cells [ 34].
IFI16 also binds to the androgen receptor to up-regulate both its expression and activity (18).
The more potent 5 α-DHT binds to the androgen receptor (AR).
Similar(43)
Synthetic and natural androgenic steroids (such as methyl-testosterone and testosterone, respectively) bind to the androgen receptor (AR), inducing an activation of the receptor (AR agonism) leading to transcription of genes responsible for androgenic effects.
If the tumor continues to grow, physicians prescribe other drugs that bind to the androgen receptor in the prostate cell's cytoplasm so that the hormone cannot land on the receptor and turn it on.
Figure 3 Three examples of searches of MTLs on the MTLD Internet server: (A) ligands that bind to the androgen receptor were queried in the "Protein" option; (B) ligands with the ligand-ID of "SAL" were queried in the "Lig" option; (C) ligands with structural similarity to that of dihydrotestosterone were queried in the "Structural" option.
In addition, certain progestogens may bind to the androgen receptor.
The androgens bind to the androgen receptor (AR) and are transported into the nucleus to initiate DNA transcription mechanisms.
More suggestions(18)
binds to the transmembrane
binds to the part
binds to the adrenomedullin
binds to the target
binds to the tail
binds to the promoter
binds to the concave
binds to the receptor
binds to the interface
binds to the cytokine
binds to the mu
binds to the acidic
binds to the plastic
binds to the drug
binds to the α4β2
binds to the prototype
binds to the adaptor
binds to the bile
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