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VpuCD (cyan) binds to the acidic dileucine binding pocket of γ/σ1, and BST2CD (magenta) binds to the tyrosine-binding pocket in μ1.
CENP-C binds to the acidic patch using two arginines, R717 and R719.
The JM region from FGFR3 binds to the acidic membrane containing PIP2.
The current data point towards a model in which the CRL3KLHL3 complex binds to the acidic degron motif leading to WNK4 ubiquitylation and proteasomal degradation.
Ubiquitin E3 ligases RNF168 and BRCA1 exhibit defective ubiquitylation when the acidic patch is mutated and IL-33 binds to the acidic patch, likely in a manner similar to the LANA nucleosome targeting peptide.
The results agree with our interpretation of the data in Figure 1, that the JM region binds to the acidic membrane in the wild-type sequence and is released from the membrane in the G380R and A391E mutant sequences.
Similar(54)
One of the structural characteristics of a neuropeptide nociceptin is the existence of Arg-Lys (RK) residues at positions 8 9 and 12 13; both RKs have been suggested to bind to the acidic amino acid cluster in the second extracellular loop of the seven transmembrane domain receptor ORL1.
Are chromatin factors that bind to the acidic patch just easier to crystallize owing to binding affinities or resultant crystal packing opportunities?
As shown in Fig. 1D, residues K624ICP0 and K1111DNMT1 both bind to the acidic cavity formed by residues E736USP7, D758USP7, E759USP7, and D764USP7, and residues K620ICP0 and K1115DNMT1 form hydrogen bonds with D684USP7 and D762USP7.
This positively charged groove on the convex side of the cullin has been reported to bind to the acidic tail of the E2 enzyme Cdc34, although patterns of conservation suggest that multiple CRL cofactors may engage this particular feature.
One loop, termed the switchback loop, binds to the H2A/H2B acidic patch using an intricate network of ionic and hydrogen bonds and van der Waals contacts.
More suggestions(18)
binds to the fatty
binds to the ph
binding to the acidic
binds to the region
binds to the insulin
binds to the enhancer
binds to the androgen
binds to the plasma
binds to the core
binds to the kinase
binds to the cell
binds to the transcription
binds to the actin
binds to the side
binds to the protein
binds to the iron
binds to the estrogen
binds to the surface
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