Sentence examples for binds to specific loci from inspiring English sources
Detection of the GFP moiety on these chromosomes revealed that SAF-B-GFP localized to discrete bands on polytene chromosomes, suggesting it binds to specific loci distributed through the genome (Fig. 5C), which are reproducible between nuclei (Fig. 5D).
However, quantitative detection of TFs bound to specific loci is a great challenge.
These fusion proteins direct virus integrations to specific loci and/or chromatin marks bound by the chromatin-binding protein.
SIR2 recruitment to the silent mating loci and telomeres requires RAP1 (repressor activator protein 1), which binds to specific silencer DNA sequences.
However, non-biased methods to identify molecules bound to specific genomic loci in vivo are limited.
In such instances, the basis of the argumentation will not be limited to common loci but to specific loci.
Under the guidance of a synthetic 20-nucleotide single guide RNA (sgRNA), Cas9 protein can bind to specific genome locus and generate targeted double-stranded break (DSBs) to facilitate efficient genome editing (Cong et al., 2013; Mali et al., 2013).
In the MaSC, Pygo2 and ß-catenin also bind to specific sites within the Axin2 locus.
While DNA-pulldowns so far have only been described to map differential binding of TFs to a specific sequence containing one or multiple nucleic acid variants, it can in theory also be used to identify the sum of TFs and co-factors that bind to a specific locus of interest.
These proteins bind to specific sites on DNA and (for example) turn on expression of specific genes.
