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Rho is a small GTPase that upon conversion from its inactive form (GDP Rho) to active form (GTP Rho) binds to specific effectors to exert its biological functions.
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The effector domain binds to specific DNA sequences of the target promoters and interacts with the cellular transcription machinery.
Fragment crystallizable (Fc) region of immunoglobulin G (IgG) antibody binds to specific Fc receptors (FcγRs) to control antibody effector functions.
The active GTP-bound form of Rac proteins bind to specific downstream effectors and thereby participate in various cellular events.
Fab portions bind to specific epitopes of target antigens whereas the Fc portion associates with immune effector cells to mediate ADCC, phagocytosis, endocytosis, release of inflammatory cytokines and antigen presentation.
This can be based on a combination of residues that bind to specific base pairs, as is the case for zinc finger proteins (ZFPs) and transcription-activator-like effectors (TALEs).
Radioiodine bound to specific vector molecules is also widely used.
Rabs are important regulators of vesicular traffic due to their capacity to recruit specific effectors.
After been pumped into host cells, the TAL effectors enter the nucleus and bind to effector-specific sequences in the host gene promoters and activate transcription.
These regulatory elements are generally composed of two domains: an aptamer that binds a specific effector molecule and an expression platform that informs the transcriptional or translational machinery.
In the physiological state, glucose-regulated protein 78 (GRP78) binds to the effectors of UPR to suppress their activities [ 34].
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