Sentence examples for binds to response elements from inspiring English sources

The induction of P450 4A enzymes by peroxisome proliferators (PPs) and fatty acids is mediated by the peroxisome proliferator activated receptor α (PPARα) that binds to response elements in target genes as a heterodimer with the retinoid X receptor (RXR).

Using the affinity-based in vitro genomic selection procedure, we have shown for the first time that Ac-DAF-16 directly binds to response elements in the hookworm genome.

PPAR-γ binds to response elements in the caveolin-1 promoter and triggers caveolin-1 transcription [ 18, 50].

The tumor suppressor p53, a nuclear transcription factor, binds to response elements in the promoter region of many genes and plays a pivotal role in apoptosis.

Activated PXR binds to response elements in the promoters and up-regulates the transcription of Phase I and II drug-metabolizing enzymes, e.g. cytochrome P450 (CYP s and glutathione S-transferases (GSTs), and transporters, e.g. multidrug resistance protein 1 (MDR1).

Upon ligand binding, the AhR binds to the aryl hydrocarbon nuclear translocator (ARNT) protein, resulting in translocation to the nucleus, where the ligand AhR ARNT complex binds to response elements in the promoter of AhR-regulated genes (dioxin response element).

In the case of PPARβ/δ [25], as with other PPARs, the genomic pathway is thought to involve binding to retinoid X receptor (RXR) and the formation of heterodimers which then bind to response elements of target genes.

Intracellular PKAcα levels and phosphorylation of HSF1 at S320 were both required for HSF1 to be localized to the nucleus, bind to response elements in the promoter of an HSF1 target gene (hsp70.1) and activate hsp70.1 after stress.

These ligand-depended transcription factors bind to response elements (RAREs or RXREs) in the promoter region of modulated genes [ 4].

When Hsp90 is functional and can assist in proper folding of GR, addition of the hormone deoxycorticosterone leads to activation of GR such that it can dimerize, translocate to the nucleus, and bind to response elements.

At the most basic level, ligand-bound NHRs can directly bind to response elements in gene promoters and recruit co-activators or co-repressors to alter the activity of the transcriptional machinery [ 43].